Last week, some parents of my child's school created a Twitter Storm asking for Pfizer for their kids.
This prompted me to look at the results of the clinical trials of Pfizer on children and to understand where Indian vaccines are on children trials.
Here is what I found. This is a summary of findings, in no particular order or form. But all the vital points are here. The recommendation is for me and my child. It is not for you or your child.
1. Just like the adult trials, the children trials did NOT check to see whether the vaccinated group had Covid or not. They checked for the child being asymptomatic. This means that 100% efficacy of Pfizer vaccine means that all the kids who got the vaccine were asymptomatic.
This also means that schools that open on that basis of this vaccination are basically unleashing millions of potential asymptomatic carriers into the world. If there is an immunocompromised child in the school (immunocompromised children cannot take the vaccine) , OR if a child's immunity is not strong enough to manage the infection with mild symptoms, that child is in serious danger because they are going to be exposed to all the variants that their friends carry without symptoms. These asymptomatic carriers also risk carrying the infection to their families.
At this time, as far as I know, the Covaxin trials have also tested RT PCR only for symptomatic cases.
2. The mRNA technology has been in the lab for over 30 years.
The no. of times it has been approved for use on humans: 0.
But as soon as the China virus erupted, there was fast track approval to these vaccines. Read this for details.
As far as I know, other than being expensive, there is NO advantage of using gene technology for this application. Dead and weakened viruses have been used for vaccination against viral diseases for a long time, and are, at this time, the safest option (read link above to understand the known risks with mRNA.)
There is, however, a risk. And that risk is, at this time, huge. If the body does not lead to an immediate autoimmune response (as given in this article), we don't know if any gradual changes will occur. The tech hasn't been around long enough for us to know that. This article mentions that because the shelf life of the mRNA is short, we can rest assured that the messenger is destroyed once the message is read. The question of - Can there be long term effects? is answered in detail -
Could there be effects decades down the track we haven't predicted? Potentially, but the transient nature of mRNA makes it one of the safer molecules we can use to combat disease.
3. Pfizer is not launching in India because it wants the Government of India to indemnify (not hold responsible) for any adverse reactions. The government has not granted such immunity to any other vaccine manufacturer, including our own Serum Institute of India and Bharat Biotech. Yesterday's paper mentioned that the govt might give conditional indemnity - that Pfizer must disclose all known adverse reactions. But here's the thing - if a safer option is available, as a consumer, I don't want to go with a company that is asking for such indemnity. Such indemnity is, in basic human terms, saying - You can take the vaccine, and if your people suffer because of that, that's not my problem. AKA avoiding responsibility. That tells me a lot about the moral fibre of the company.
4. The US is using Pfizer for all its citizens. Pfizer is its home grown vaccine. For India, Pfizer would mean expensive imports. These expensive imports are completely justifiable if the protection rate is significantly higher. But that is not the case.
The US is not importing any vaccines. All the 3 vaccines currently approved for use in the US - Moderna, Pfizer, and JnJ, are made in the US.
Further, Covaxin's children's trials have started on April 30th. We can wait for them to appear, but since the tech is fairly well known, we know that they are likely to be successful. Indian children have also tolerated such vaccines successfully as part of our national vaccination program. We have NO IDEA how Indians - adults and children, and our unique genetic makeup, will respond to the vaccine. This is not a fancy idea. The variants that have mutated in India are a result of the body's response to the RNA of the virus. These mutations have happened during the RNA- ACE2 dance based on the Indian population's unique genes.
Conclusion
So, all things considered, as a parent, and as a consumer, I do not want the government to give indemnity to Pfizer. I do not want the Pfizer vaccine for my child. And I definitely am not sending my child to school on the basis of Pfizer global vaccination coverage.
There is very little chance that the American population will see another China Virus wave after this immunisation. Because, as Nicolas Wade points out, it was the US that funded this virus' creation, and the US that will benefit from the vaccine commerce. So, it would not want a second public health emergency. Besides, Biden is in the White House and China is now secure. No more trade sanctions, no more local manufacturing stimulus, no issues at all. It makes sense for China to not cause a second wave in the US. One does not stress one's largest customer, after all.
But India does not have the same good luck. It is in China's interest to ensure a weak India - both militarily and financially. Only India has stood against China's economic colonialism in Pakistan, Sri Lanka, Nepal, and even Bhutan now. A weakened India, like the one we experienced this month, is very much to the benefit of China. So, i dont think that Pfizer will be as successful in India as it will be in the US.
Reference:
1. A single-dose mRNA vaccine provides a long-term protection for hACE2 transgenic mice from SARS-CoV-2 | Nature Communications